Evaluation of the Thrombolytic and Antioxidant Activity of Leaf Extracts of Plumbago zeylanica L.

Abstract: Background: Plumbago zeylanica L. is one of the extremely accessible conventionally used herbal plants with various biological activities. However, actions P. L on blood clotting and other complications were indisposed therapeutically studied. Therefore, scope current exploration to screen thrombolytic, antioxidant, cytotoxic effects leaf extracts. Materials Methods: Thrombolytic activity (in vitro) was assessed clot lysis thrombin inhibitory ability. Further, thrombolytic vivo) evaluated by a thrombotic tail (carrageenan-induced) animal model. DPPH nitric oxide (free radical) scavenging methods employed check in vitro antioxidant property. Further cytotoxicity acute oral toxicity for plant extract. Results: The quantitative analysis elicits presence magnificent amount total phenolic content (96.8±7.92 mg GAE/g) flavonoid (63.52±4.54 QE/g) dry weight basis. maximum (96.83%±0.657) methanolic extract detected model at 800 μg/mL 72 hr. A strong inhibition (94.63±2.12%) effect observed methanol 2 mg/mL. In vivo studies significant (p< 0.001) achieved tested dose (100, 200 300 mg/kg). radical showed IC50 value 25.47±0.51 56.32±0.85, respectively. found safer up highest lethal 2000 mg/kg. Conclusion: These findings suggested that leaves are comprised properties. It could be promising source existence agents. Keywords: L., activity, Anti-oxidant Cytotoxicity, Streptokinase, etc.